Vitamin D receptor hypermethylation as a biomarker for pediatric adrenocortical tumors.
Ana Carolina BuenoMônica F StecchiniJunier Marrero-GutiérrezCandy Bellido MoreLeticia Ferro LealDébora Cristiane GomesDaniel Ferreira de Lima NetoSilvia Regina BrandaliseIzilda Aparecida CardinalliJosé Andres YunesThais JunqueiraCarlos Alberto ScrideliCarlos Augusto Fernandes MolinaFernando Silva RamalhoSilvio TucciFernanda Borchers Coeli-LacchiniAyrton Custodio MoreiraLeandra RamalhoRicardo Zorzetto Nicoliello VêncioMargaret De CastroSonir Roberto Rauber AntoniniPublished in: European journal of endocrinology (2022)
VDR has a role in normal adrenocortical development and homeostasis, which is impaired during tumorigenesis. VDR hypermethylation and underexpression may be both predictive and prognostic biomarkers for pACT.
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