Associations of Epigenetic Age Estimators With Cognitive Function Trajectories in the Women's Health Initiative Memory Study.
Steve NguyenLinda K McEvoyMark A EspelandEric A WhitselAke LuSteve HorvathJo Ann E MansonStephen R RappAladdin H ShadyabPublished in: Neurology (2024)
ε4 carriers. DunedinPACE may help identify older women at risk of future cognitive decline. Limitations include the ancillary studies that collected epigenetic data not designed to study epigenetics and cognitive function. We examined epigenetic age estimators with global cognitive function and not specific cognitive domains. Findings may not generalize to men and more diverse populations.
Keyphrases
- cognitive decline
- dna methylation
- gene expression
- public health
- mild cognitive impairment
- healthcare
- mental health
- metabolic syndrome
- polycystic ovary syndrome
- quality improvement
- machine learning
- electronic health record
- climate change
- big data
- risk assessment
- adipose tissue
- health information
- middle aged
- artificial intelligence
- pregnant women
- current status