PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancer.

Danna YeerkenRuoxi HongYan WangYing GongRui LiuDi YangJinting LiJiawen FanJie ChenWeimin ZhangQimin Zhan

Published in: PloS one (2020)

Our study provided a new insight into the dysregulation of glycolysis in breast cancer, which might be partially due to the deficiency of BRCA1/ZBRK1 axis and subsequently reversed the transcriptional repressive effect on PFKP. We also found that PFKP overexpressed in a subset of breast cancer patients and could serve as a prognostic factor, which represented a potential target for BC therapy.

Keyphrases

prognostic factors
breast cancer risk
gene expression
transcription factor
stem cells
young adults
replacement therapy
human health
risk assessment
heat shock
oxidative stress