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PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancer.

Danna YeerkenRuoxi HongYan WangYing GongRui LiuDi YangJinting LiJiawen FanJie ChenWeimin ZhangQimin Zhan
Published in: PloS one (2020)
Our study provided a new insight into the dysregulation of glycolysis in breast cancer, which might be partially due to the deficiency of BRCA1/ZBRK1 axis and subsequently reversed the transcriptional repressive effect on PFKP. We also found that PFKP overexpressed in a subset of breast cancer patients and could serve as a prognostic factor, which represented a potential target for BC therapy.
Keyphrases
  • prognostic factors
  • breast cancer risk
  • gene expression
  • transcription factor
  • stem cells
  • young adults
  • replacement therapy
  • human health
  • risk assessment
  • heat shock
  • oxidative stress