Obesity modifies the energetic phenotype of dilated cardiomyopathy.
Jennifer J RaynerMark A PeterzanWilliam T ClarkeChristopher T RodgersStefan NeubauerOliver J RiderPublished in: European heart journal (2021)
In normal weight, DCM is associated with reduced resting ATP delivery. In obese DCM, ATP demand through CK is greater, suggesting reduced efficiency of energy utilization. Dietary weight loss is associated with significant improvement in myocardial contractility, and a fall in ATP delivery, suggesting improved metabolic efficiency. This highlights distinct energetic pathways in obesity cardiomyopathy, which are both different from dilated cardiomyopathy, and may be reversible with weight loss.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- gastric bypass
- weight gain
- glycemic control
- heart failure
- heart rate
- obese patients
- left ventricular
- heart rate variability
- metabolic syndrome
- type diabetes
- insulin resistance
- blood pressure
- protein kinase
- adipose tissue
- body mass index
- atrial fibrillation
- high fat diet induced