Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40.
Caitlin N SuireSamer O Abdul-HayTomoko SaharaDongcheul KangMonica K BrizuelaPaul SaftigDennis W DicksonTerrone L RosenberryMalcolm A LeissringPublished in: Alzheimer's research & therapy (2020)
Our findings identify CatD as the principal intracellular Aβ-degrading protease identified to date, one that regulates Aβ42/40 ratios via differential degradation of Aβ42 vs. Aβ40. The finding that Aβ42 is a potent competitive inhibitor of CatD suggests a possible mechanistic link between elevations in Aβ42 and downstream pathological sequelae in AD.