BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer.
Liliana RaimundoAngela PaternaJuliana CalheirosJoana RibeiroDavid S P CardosoIlaria PigaSusana Junqueira NetoDenise HeganPeter M GlazerStefano IndraccoloSilva MulhovoJosé Luís CostaMaria-José U FerreiraLucília SaraivaPublished in: British journal of pharmacology (2021)
These findings add an inhibitor of the BRCA1-BARD1 interaction to the list of DNA-damaging agents. Importantly, either as a single agent or in combination therapy, BBIT20 reveals great potential in the personalized treatment of aggressive and resistant cancers, particularly triple-negative breast and advanced ovarian cancer.