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BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer.

Liliana RaimundoAngela PaternaJuliana CalheirosJoana RibeiroDavid S P CardosoIlaria PigaSusana Junqueira NetoDenise HeganPeter M GlazerStefano IndraccoloSilva MulhovoJosé Luís CostaMaria-José U FerreiraLucília Saraiva
Published in: British journal of pharmacology (2021)
These findings add an inhibitor of the BRCA1-BARD1 interaction to the list of DNA-damaging agents. Importantly, either as a single agent or in combination therapy, BBIT20 reveals great potential in the personalized treatment of aggressive and resistant cancers, particularly triple-negative breast and advanced ovarian cancer.
Keyphrases
  • dna repair
  • combination therapy
  • dna damage
  • dna damage response
  • circulating tumor
  • breast cancer risk
  • cell free
  • oxidative stress
  • risk assessment
  • climate change
  • circulating tumor cells