LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force.
Duarte M S FerreiraArthur J ChengLeandro Z AgudeloIgor CervenkaThomas ChaillouJorge C CorreiaMargareta Porsmyr-PalmertzManizheh IzadiAlicia HanssonVicente Martínez-RedondoPaula Valente-SilvaAmanda T Pettersson-KleinJennifer L EstallMatthew M RobinsonK Sreekumaran NairJohanna T LannerJorge L RuasPublished in: Skeletal muscle (2019)
Our gain- and loss-of-function studies show that LMCD1 controls protein synthesis, muscle fiber size, specific force, Ca2+ handling, and fatigue resistance. This work uncovers a novel role for LMCD1 in the regulation of skeletal muscle mass and function with potential therapeutic implications.