Development of multivalent nanobodies blocking SARS-CoV-2 infection by targeting RBD of spike protein.

Qizhong LuZongliang ZhangHexian LiKunhong ZhongQin ZhaoZeng WangZhiguo WuDonghui YangShuang SunNian YangMeijun ZhengQiang ChenCheng LongWenhao GuoHui YangChunlai NieAiping Tong

Published in: Journal of nanobiotechnology (2021)

The present study indicated that naïve VHH library could be used as a potential resource for rapid acquisition and exploitation of antiviral nanobodies. Heterodimer nanobody Nb91-Nb3-hFc may serve as a potential therapeutic agent for the treatment of COVID-19.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
small molecule
risk assessment
human health
climate change