BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability.
Maria P SilvaLuísa T FerreiraNatércia F BrásLurdes TorresAndreia BrandãoManuela PinheiroMarta CardosoAdriana ResendeJoana VieiraCarlos PalmeiraGabriela MartinsMiguel SilvaCarla PintoAna PeixotoJoão SilvaRui HenriqueSofia MaiaHelder MaiatoManuel R TeixeiraPaula PauloPublished in: Journal of biomedical science (2024)
Our study shows that different BUB1B variants may uncover a trigger for CIN-driven carcinogenesis, supporting the role of BUB1B as a (pan)-cancer predisposing gene with potential impact on genetic counseling and treatment decision-making.
Keyphrases
- copy number
- prostate cancer
- genome wide
- decision making
- papillary thyroid
- dna methylation
- radical prostatectomy
- squamous cell
- smoking cessation
- squamous cell carcinoma
- gene expression
- risk assessment
- transcription factor
- human health
- young adults
- climate change
- childhood cancer
- human immunodeficiency virus
- men who have sex with men
- antiretroviral therapy