Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors.
Changhua JiMarc D RoyJonathan GolasAllison VitskySripad RamSteven W KumpfMatthew MartinFrank BarlettaWilliam A MeierAndrea T HooperPuja SapraNasir K KhanMartin FinkelsteinMagali GuffroyBernard S BuetowPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
We have developed a monkey model characterized by multiple organ toxicities including myocarditis. This model may provide insight into the immune mechanisms and facilitate biomarker identification for ICI-associated irAEs.
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