Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity.

Our findings suggest that irregular stimulation patterns are not useful where the desired therapeutic mechanism is to suppress or enhance a single frequency band. However, novel stimulation patterns may provide the greatest benefit for neurological conditions where entraining a mixture of bands (e.g. if they are associated with different symptoms) or desired behaviorally relevant neural states is a potential therapeutic mechanism.