Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing Rac2 Is Required for Efferocytosis Internalization and Reduction of Atherosclerosis Development.

Jian ZhangXiangkai ZhaoYunyun GuoZhiping LiuShujian WeiQiuhuan YuanHaixia ShangWentao SangSumei CuiTonghui XuKehui YangJialin GuoChang PanJiali WangJiaojiao PangTianrui HanYuguo ChenFeng Xu

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Our study has uncovered a pivotal role of the ALDH2-Rac2 axis in mediating efferocytosis during atherosclerosis, highlighting a potential therapeutic strategy in cardiovascular diseases, especially for ALDH2 rs671 mutation carriers.

Keyphrases

cardiovascular disease
adipose tissue
cell migration
type diabetes
metabolic syndrome
cardiovascular risk factors
cardiovascular events