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Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway.

Yinong DuanJing PanJinling ChenDandan ZhuJianxin WangXiaolei SunLiuting ChenLiting Wu
Published in: PLoS neglected tropical diseases (2016)
The present study demonstrates that SEA promotes HSCs senescence through the FoxO3a/SKP2/P27 pathway.
Keyphrases
  • induced apoptosis
  • transcription factor
  • dna damage
  • signaling pathway
  • pi k akt
  • endothelial cells
  • cell cycle arrest
  • stress induced
  • dendritic cells
  • cell death