Is there any association between rs1303 (Pi*M3) variant of alpha-1 antitrypsin gene and atrial septal aneurysm development?

Fatma Nihan Turhan CaglarNilgun IsiksacanIsmail BiyikHande Oktay TureliFahrettin KatkatDilay KarabulutDidem Melis Oztas Murat Uğurlucan

Published in: Journal of cardiac surgery (2019)

This preliminary study revealed that homozygote A1AT rs1303 (PiM3M3) variant is significantly higher in patients with isolated ASA and may be associated with ASA development. Large scale comprehensive studies are needed to validate these results.

Keyphrases

atrial fibrillation
genome wide
copy number
heart failure
single cell
hypertrophic cardiomyopathy
left atrial
left ventricular
dna methylation
case control
genome wide identification