Effects of codeine on esophageal peristalsis in humans using high resolution manometry.

Chien-Lin Chen Ming-Wun WongJui-Sheng HungShu-Wei LiangTso-Tsai LiuChih-Hsun YiLin LinWilliam C OrrWei-Yi Lei

Published in: Journal of gastroenterology and hepatology (2021)

In addition to impair LES relaxation and reduce distal latency of primary peristalsis, codeine impairs LES relaxation of secondary peristalsis and increases secondary peristaltic frequency. Our study supports the notion in human esophagus that the impact of opioids on peristaltic physiology appears to be present in both primary and secondary peristalsis.

Keyphrases

high resolution
endothelial cells
single molecule
chronic pain
pain management
mass spectrometry
induced pluripotent stem cells
high speed
gastroesophageal reflux disease