Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines.

Thomas W McDadeCalen P RyanLinda S AdairNanette R LeeDelia B CarbaJulia L MacIsaacKristy DeverParmida AtashzayMichael S KoborChristopher W Kuzawa

Published in: American journal of human biology : the official journal of the Human Biology Council (2023)

We document negative associations between measures of infectious exposure in infancy and DNA methylation-based measures of aging. Additional research, across a wider range of epidemiological settings, is needed to clarify the role of infectious disease in shaping immunophenotypes and trajectories of biological aging and human life expectancy.

Keyphrases

dna methylation
infectious diseases
depressive symptoms
gene expression
endothelial cells
weight gain
genome wide
induced pluripotent stem cells
air pollution
body mass index
copy number
early life