Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes.

Wenqian CaiDacai XuChui ZengFan LiaoRuiqi LiYingjiong LinYue ZhaoWenyan DongQingwen WangHaili YangDaqiang WenJianbiao GuWeihui ShentuHongkui YuXiaochun ZhangJian-Rui Wei Jinzhu Duan

Published in: Circulation research (2022)

Our results indicate that Kcr modulation is a key response of cardiomyocytes to ischemia-reperfusion injury and may represent a novel therapeutic target in the context of ischemic heart disease.

Keyphrases

ischemia reperfusion injury
oxidative stress
high glucose
left ventricular
signaling pathway
heart failure
endothelial cells
type diabetes
metabolic syndrome
adipose tissue
weight loss
insulin resistance