Blockade of the mitochondrial DNA release ameliorates hepatic ischemia-reperfusion injury through avoiding the activation of cGAS-Sting pathway.

Yi XiongJiawen ChenWei LiangKun LiYingqi HuangJingwen SongBaoyu ZhangXiusheng QiuDongbo QiuQi ZhangYunfei Qin

Published in: Journal of translational medicine (2024)

The results of our study suggest that the release of mtDNA plays a significant role in causing damage to liver by activating the cGAS-STING pathway during I/R injury. Furthermore, inhibiting the release of mtDNA can provide effective protection against hepatic I/R injury.

Keyphrases

mitochondrial dna
copy number
ischemia reperfusion injury
signaling pathway
oxidative stress
genome wide
mouse model