MiR-26a and miR-138 block the G1/S transition by targeting the cell cycle regulating network in prostate cancer cells.
Kati ErdmannKnut KaulkeChristiane RiegerKarsten SalomoManfred P WirthSusanne FuesselPublished in: Journal of cancer research and clinical oncology (2016)
The present findings suggest an anti-proliferative role for miR-26a and miR-138 in PCa by blocking the G1/S-phase transition independent of EZH2 but via a concerted inhibition of crucial cell cycle regulators.