Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease.
Cornelis BlauwendraatHirotaka IwakiMary B MakariousSara Bandres-CigaHampton L LeonardFrancis P GrennJulie LakeLynne KrohnManuela TanJonggeol J KimJesse R GibbsDena G HernandezJennifer A RuskeyLasse PihlstromMathias ToftJacobus J van HiltenJohan MarinusClaudia SchulteKathrin BrockmanManu SharmaAri SiitonenKari MajamaaJohanna Eerola-RautioPentti J TienariDonald G GrossetSuzanne LesageJean-Christophe CorvolAlexis BriceNick WoodJohn HardyZiv Gan OrPeter HeutinkThomas GasserHuw R MorrisAlastair J NoyceMike A NallsAndrew B Singletonnull nullPublished in: Annals of neurology (2021)
We did not detect any significant genetic differences between male or female PD cases. Our study does not support the notion that common genetic variation on the autosomes could explain the difference in prevalence of PD between males and females cases at least when considering the current sample size under study. Further studies are warranted to investigate the genetic architecture of PD explained by X and Y chromosomes and further evaluate environmental effects that could potentially contribute to PD etiology in male versus female patients. ANN NEUROL 2021;90:41-48.