Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions.
Di LiuJian-Jun GuoJi-Hui SuAlexander SvanbergssonLin YuanCaroline HaikalWen LiGunnar GourasJun-Fang TengPublished in: Translational neurodegeneration (2021)
The different α-syn conformers generated in different conditions exhibited strain-specific pathology and propagation patterns from the periphery to the CNS, which further supports the view that α-syn strains may be responsible for the heterogeneity of pathological features and disease progresses among synucleinopathies.
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