Prognostic impact of perineural invasion in intrahepatic cholangiocarcinoma: multicentre study.
Tao WeiXu-Feng ZhangJin HeIrinel PopescuHugo P MarquesLuca A AldrighettiShishir K MaithelCarlo PulitanoTodd W BauerFeng ShenGeorge A PoultsidesOliver SoubraneGuillaume MartelBas Groot KoerkampEndo ItaruYi LvTimothy M PawlikPublished in: The British journal of surgery (2022)
PNI is a strong independent predictor of tumour recurrence and long-term survival following resection of ICC with curative intent, even among patients with early-stage disease. The presence of PNI should be assessed routinely.