The Emerging Role of Irisin in Cardiovascular Diseases.
Jinjuan FuFangtang LiYuanjuan TangLin CaiChunyu ZengYong-Jian YangJian YangPublished in: Journal of the American Heart Association (2021)
Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane-spanning protein, FNDC5 (fibronectin type III domain-containing protein 5). The current knowledge on the biological functions of irisin includes browning white adipose tissue, regulating insulin use, and anti-inflammatory and antioxidative properties. Dysfunction of irisin has shown to be involved in cardiovascular diseases such as hypertension, coronary artery disease, myocardial infarction, and myocardial ischemia-reperfusion injury. Moreover, irisin gene variants are also associated with cardiovascular diseases. In this review, we discuss the current knowledge on irisin-mediated regulatory mechanisms and their roles in the pathogenesis of cardiovascular diseases.
Keyphrases
- cardiovascular disease
- type iii
- adipose tissue
- coronary artery disease
- anti inflammatory
- healthcare
- ischemia reperfusion injury
- type diabetes
- left ventricular
- heart failure
- copy number
- blood pressure
- cardiovascular risk factors
- transcription factor
- cardiovascular events
- amino acid
- insulin resistance
- gene expression
- protein protein
- skeletal muscle
- percutaneous coronary intervention
- arterial hypertension
- genome wide analysis