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Identification, discrimination and heterogeneity of fibroblasts.

Urban LendahlLars MuhlChrister Betsholtz
Published in: Nature communications (2022)
Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix components during tissue development, homeostasis, repair and disease. Despite this crucial role, the identification and distinction of fibroblasts from other cell types are challenging and laden with caveats. Rapid progress in single-cell transcriptomics now yields detailed molecular portraits of fibroblasts and other cell types in our bodies, which complement and enrich classical histological and immunological descriptions, improve cell class definitions and guide further studies on the functional heterogeneity of cell subtypes and states, origins and fates in physiological and pathological processes. In this review, we summarize and discuss recent advances in the understanding of fibroblast identification and heterogeneity and how they discriminate from other cell types.
Keyphrases
  • single cell
  • rna seq
  • extracellular matrix
  • cell therapy
  • high throughput
  • stem cells
  • bone marrow
  • single molecule
  • sensitive detection
  • loop mediated isothermal amplification