Downregulation of DNA methyltransferase-3a ameliorates the osteogenic differentiation ability of adipose-derived stem cells in diabetic osteoporosis via Wnt/β-catenin signaling pathway.

Maorui ZhangYujin GaoQing LiHuayue CaoJianghua YangXiaoxiao CaiJingang Xiao

Published in: Stem cell research & therapy (2022)

Dnmt3a silencing rescues the negative effects of DOP on ASCs and provides a possible approach for bone tissue regeneration in patients with diabetic osteoporosis.

Keyphrases

wound healing
bone mineral density
postmenopausal women
stem cells
cell proliferation
type diabetes
mouse model
mesenchymal stem cells
dna methylation
body composition
signaling pathway
cell free
single molecule
gene expression