Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus.

Bettadapura N Srikumar Pattipati S NaiduNarasimharaju KalidindiMahesh PaschapurBharath AdepuSiva SubramaniJignesh NagarRatika SrivastavaMuppana V SreedharaDurga Shiva PrasadManish Lal DasJustin V LouisVijaya K KuchibhotlaShailesh DudhgaonkarRick L PieschlYu-Wen LiLinda J BristowManjunath RamaraoReeba K Vikramadithyan

Published in: Journal of psychopharmacology (Oxford, England) (2018)

In summary, the MRL/lpr mice could be a useful model for Treatment Resistant Depression associated with immune dysfunction with potential to expedite antidepressant drug discovery.

Keyphrases

drug discovery
major depressive disorder
mouse model
systemic lupus erythematosus
depressive symptoms
bipolar disorder
high fat diet induced
disease activity
oxidative stress
pain management
sleep quality
human health
type diabetes
risk assessment
skeletal muscle
climate change