Vascular Inflammation and Dysfunction in Lupus-Prone Mice-IL-6 as Mediator of Disease Initiation.

Paul MarczynskiMyriam MeineckNing XiaHuige LiDaniel KrausWilfried RothTamara MöckelSimone BoedeckerAndreas SchwartingJulia Weinmann-Menke

Published in: International journal of molecular sciences (2021)

Our findings demonstrate that the MRL-Faslpr mouse model is an excellent tool to investigate vascular damage in SLE mice. Moreover, IL-6 promotes vascular inflammation and damage and could potentially be a therapeutic target for the treatment of accelerated arteriosclerosis in SLE.

Keyphrases

oxidative stress
systemic lupus erythematosus
disease activity
mouse model
high fat diet induced
rheumatoid arthritis
type diabetes
insulin resistance
metabolic syndrome
skeletal muscle
smoking cessation