Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study.

Cristiana CruceanuLeander DonyAnthi C KrontiraDavid S FischerSimone RoehRossella Di GiaimoChristina KyrousiLea KasparJanine ArlothDarina CzamaraNathalie GerstnerSilvia MartinelliStefanie WehnerMichael S BreenMaik KoedelSusann SauerVincenza SportelliMonika Rex-HaffnerSilvia CappelloFabian J TheisElisabeth B Binder

Published in: The American journal of psychiatry (2021)

These findings suggest that excessive glucocorticoid exposure could interfere with neuronal maturation in utero, leading to increased disease susceptibility through neurodevelopmental processes at the interface of genetic susceptibility and environmental exposure. Cerebral organoids are a valuable translational resource for exploring the effects of glucocorticoids on early human brain development.

Keyphrases

cerebral ischemia
subarachnoid hemorrhage
white matter
genome wide
weight gain
copy number
gene expression
human health
body mass index
physical activity
binding protein