A pharmacokinetic-pharmacodynamic study of a single dose of febuxostat in healthy subjects.
Bishoy KamelGarry G GrahamSophie Lena StockerZhixin LiuKenneth M WilliamsJane Ellen CarlandKevin D PileRichard O DayPublished in: British journal of clinical pharmacology (2020)
The PK-PD model could potentially be used to individualise febuxostat treatment and improve clinical outcomes. A single dose of febuxostat does not affect the efficiency of the kidney to excrete urate. Further investigations are required to confirm the present results following multiple dosing with febuxostat.
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