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Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252.

Yanhe LiXiaoming LiXin LiSuiqun YangBin-Gui WangHong-Lei Li
Published in: International journal of molecular sciences (2022)
Six novel verrucosidin derivatives, namely, poloncosidins A-F ( 1 - 6 ), together with one known analogue ( 7 ), were isolated and identified from the deep-sea-derived fungus Penicillium polonicum CS-252, which was obtained from cold-seep sediments collected in the South China Sea at a depth of 1183 m. Their structures were mainly established on the basis of a detailed interpretation of NMR spectroscopic and mass spectrometric data. The relative and absolute configurations of compounds 1 - 6 were determined by ECD calculations and a DP4+ probability analysis. Compounds 1 - 5 represent the first examples of verrucosidins with a 2,5-dihydrofuran ring which is uncommon among the known analogues. These compounds exhibited inhibitory activities against several human and aquatic pathogens with MIC values ranging from 4 to 32 μg/mL.
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