Sarcopenia in Neurological Patients: Standard Values for Temporal Muscle Thickness and Muscle Strength Evaluation.
Ariane SteindlJohannes LeitnerMatthias SchwarzKarl-Heinz NenningUlrika AsenbaumSophie MayerRamona WoitekMichael WeberVeronika SchöpfAnna S BerghoffThomas BergerGeorg WidhalmDaniela PrayerMatthias PreusserJulia FurtnerPublished in: Journal of clinical medicine (2020)
Temporal muscle thickness (TMT) was investigated as a novel surrogate marker on MRI examinations of the brain, to detect patients who may be at risk for sarcopenia. TMT was analyzed in a retrospective, normal collective cohort (n = 624), to establish standard reference values. These reference values were correlated with grip strength measurements and body mass index (BMI) in 422 healthy volunteers and validated in a prospective cohort (n = 130) of patients with various neurological disorders. Pearson correlation revealed a strong association between TMT and grip strength (retrospective cohort, ρ = 0.746; p < 0.001; prospective cohort, ρ = 0.649; p < 0.001). A low or no association was found between TMT and age (retrospective cohort, R2 correlation coefficient 0.20; p < 0.001; prospective cohort, ρ = -0.199; p = 0.023), or BMI (retrospective cohort, ρ = 0.116; p = 0.042; prospective cohort, ρ = 0.227; p = 0.009), respectively. Male patients with temporal wasting and unintended weight loss, respectively, showed significantly lower TMT values (p = 0.04 and p = 0.015, unpaired t-test). TMT showed a high correlation with muscle strength in healthy individuals and in patients with various neurological disorders. Therefore, TMT should be integrated into the diagnostic workup of neurological patients, to prevent, delay, or treat sarcopenia.
Keyphrases
- body mass index
- skeletal muscle
- end stage renal disease
- newly diagnosed
- weight loss
- ejection fraction
- chronic kidney disease
- prognostic factors
- weight gain
- magnetic resonance imaging
- patient reported outcomes
- cerebral ischemia
- magnetic resonance
- optical coherence tomography
- white matter
- high resolution
- roux en y gastric bypass
- gastric bypass
- brain injury
- blood brain barrier
- subarachnoid hemorrhage