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Pharmacological management of secondary chronic spinal cord injury: a systematic review.

Filippo MiglioriniFederico CocconiLuise SchäferFrancesco SimeoneMadhan JeyaramanNicola Maffulli
Published in: British medical bulletin (2024)
Different approaches exist for the pharmacological management of secondary chronic SCI. One of the most investigated drugs, 4-aminopyridine, improves central motor conduction and shows improvement in neurological signs. Positive results in different areas have been observed in patients receiving the anti-spastic drugs tizanidine and baclofen or Granulocyte colony-stimulating factor. Growth hormone showed only minimal or no significant effects, and the therapy of secondary chronic SCI with riluzole has been poorly researched to date.
Keyphrases
  • spinal cord injury
  • growth hormone
  • drug induced
  • spinal cord
  • stem cells
  • bone marrow
  • brain injury
  • cerebral palsy
  • mesenchymal stem cells
  • cell therapy
  • single molecule