Rab22a Promotes Epithelial-Mesenchymal Transition in Papillary Thyroid Carcinoma by Activating PI3K/AKT/mTOR Signaling Pathway.

Xue LuoJinping WangJinxi LuXi WangYuan MiaoQingchang LiXiaoman LiEn-Hua Wang

Published in: BioMed research international (2022)

Rab22a can promote the EMT process and enhance proliferation, migration, and invasion of papillary thyroid carcinoma cells by activating the PI3K/AKT/mTOR signaling pathway. Our study provides new pathological diagnosis clues and clinical treatment targets for thyroid cancer.

Keyphrases

signaling pathway
epithelial mesenchymal transition
induced apoptosis
pi k akt
lymph node metastasis
lymph node
cell cycle arrest
transforming growth factor
squamous cell carcinoma
endoplasmic reticulum stress
oxidative stress