The effect of caffeine on cognitive performance is influenced by CYP1A2 but not ADORA2A genotype, yet neither genotype affects exercise performance in healthy adults.
Alexander T CarswellKevin HowlandBorja Martinez-GonzalezPauline BaronGlen DavisonPublished in: European journal of applied physiology (2020)
Caffeine enhanced CYP1A2 'fast' metabolisers' cognitive performance more than 'slow' metabolisers. No other between-genotype differences emerged for the effect of caffeine on exercise or cognitive performance, or metabolism.