Effect of selective IK,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation.

Merle Friederike FennerHelena CarstensenSarah Dalgas NissenEva Melis HesselkildeChristine Scott LunddahlMaja Adler Hess JensenAmeli Victoria Loft-AndersenStefan Michael SattlerPyotr PlatonovSaid El-HaouClaire JacksonRaymond TangRobert KirbyJohn FordUlrich SchottenJames MilnesUlrik Svane SørensenThomas JespersenRikke Buhl

Published in: British journal of pharmacology (2020)

XAF-1407 efficiently cardioverted sustained tachypacing-induced AF of short duration in horses without notable side effects. This supports IK,ACh inhibition as a potentially safe treatment of paroxysmal AF in horses, suggesting potential clinical value for other species including humans.

Keyphrases

atrial fibrillation
high glucose
diabetic rats
catheter ablation
left atrial
oral anticoagulants
left atrial appendage
heart failure
direct oral anticoagulants
drug induced
oxidative stress
coronary artery disease
risk assessment
left ventricular
combination therapy
venous thromboembolism
human health