Optimal control of combination immunotherapy for a virtual murine cohort in a glioblastoma-immune dynamics model.

Hannah G Anderson Gregory P Takacs Jeffrey K Harrison Libin Rong Tracy L Stepien

Published in: bioRxiv : the preprint server for biology (2024)

A mathematical model of glioma-immune dynamics integrates combination immunotherapy.An optimized regimen extends survival in an average virtual mouse by 79 days.Quality of life and survival outcomes were evaluated for a virtual murine cohort.A high death rate of myeloid-derived suppressor cells predicts long-term survival.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
cell death
signaling pathway