Long term effects of fetal undernutrition on rat heart. Role of hypertension and oxidative stress.
Pilar Rodríguez-RodríguezAngel L López de PabloConcha F García-PrietoBeatriz SomozaBegoña Quintana-VillamandosJosé J Gómez de DiegoPerla Y Gutierrez-ArzapaloDavid Ramiro-CortijoM Carmen GonzálezSilvia Magdalena ArribasPublished in: PloS one (2017)
1) During perinatal life females exposed to fetal undernutrition are protected from cardiac alterations, but in ageing they exhibit ventricular hypertrophy and functional loss, like MUN males; 2) cardiac oxidative stress might be implicated in the observed heart alterations in both sexes and 3) the severity of cardiac damage might be greater in males due to hypertension.