Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition.

Izzuddin Bin NadzirinAnna Fortuny-GomezNeville NgumDavid RichardsSeema AliMark SearceySamuel J Fountain

Published in: British journal of pharmacology (2021)

Taspine is a novel natural product P2X4 receptor inhibitor, mediating its effect through PI3-kinase inhibition rather than receptor antagonism. Taspine can inhibit the pro-inflammatory signalling by P2X4 in human primary macrophage.

Keyphrases

endothelial cells
adipose tissue
tyrosine kinase
protein kinase
binding protein
induced pluripotent stem cells