LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement.
Christos P KyriakopoulosChris J KapeliosElizabeth L StauderIosif TalebRana HamoucheKonstantinos SiderisAntigone G KoliopoulouMichael J BoniosStavros G DrakosPublished in: Journal of clinical medicine (2022)
Left ventricular assist devices (LVADs) are an established treatment modality for advanced heart failure (HF). It has been shown that through volume and pressure unloading they can lead to significant functional and structural cardiac improvement, allowing LVAD support withdrawal in a subset of patients. In the first part of this review, we discuss the historical background, current evidence on the incidence and assessment of LVAD-mediated cardiac recovery, and out-comes including quality of life after LVAD support withdrawal. In the second part, we discuss current and future opportunities to promote LVAD-mediated reverse remodeling and improve our pathophysiological understanding of HF and recovery for the benefit of the greater HF population.
Keyphrases
- left ventricular
- heart failure
- left ventricular assist device
- acute heart failure
- cardiac resynchronization therapy
- end stage renal disease
- hypertrophic cardiomyopathy
- ejection fraction
- acute myocardial infarction
- newly diagnosed
- aortic stenosis
- left atrial
- mitral valve
- chronic kidney disease
- peritoneal dialysis
- risk factors
- electronic health record
- disease activity
- machine learning
- rheumatoid arthritis
- patient reported outcomes
- coronary artery disease
- combination therapy
- systemic lupus erythematosus
- smoking cessation