LncRNA IL21-AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus.

Limin LiuLongyuan HuHaojun LongMeiling ZhengZhi HuYe HeXiaofei GaoPei DuHongjun ZhaoDi YuQianjin LuMing Zhao

Published in: Clinical and translational medicine (2022)

Our results demonstrate that IL21-AS1 activates IL21 transcription via epigenetic mechanism to promote germinal centre response, adding insight into the molecular regulation of autoimmune pathogenesis and providing a novel target for SLE treatment.

Keyphrases

systemic lupus erythematosus
induced apoptosis
dna methylation
gene expression
transcription factor
cell proliferation
rheumatoid arthritis
binding protein
cell cycle arrest
cell death
disease activity
small molecule
combination therapy
drug induced