Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study.
Emmet CostelloJames P K RooneyMarta Pinto-GrauTom BurkeMarwa ElaminPeter BedeRoisin McMackinStefan DukicAlice VajdaMark HeverinOrla HardimanNiall PenderPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
These findings suggest that CR plays a role in the presentation of cognitive impairment at diagnosis but is not protective against cognitive decline. However, further research is needed to examine the interaction between CR and other objective correlates of cognitive impairment in ALS.