Regulation of immune response genes in the skin of allergic and clinically tolerant individuals exposed to p-phenylenediamine.

Sanne S MeisserYasutaka MitamuraCan AltunbulakliJosefine BandierMorten S OpstrupAnne-Sofie Østergaard GadsbøllManru LiGe Tan Mübeccel Akdiş Mübeccel Akdis Carsten GeislerJeanne D JohansenCharlotte Menné Bonefeld

Published in: Allergy (2024)

This study demonstrates that there are no true non-responders to PPD but that the immune response elicited by PPD differs between individuals and can lead to either tolerance, subclinical inflammation or allergy.

Keyphrases

immune response
oxidative stress
dendritic cells
toll like receptor
genome wide
atopic dermatitis
gene expression
wound healing
inflammatory response
transcription factor
bioinformatics analysis
allergic rhinitis