Transcription-Coupled Repair of DNA Interstrand Crosslinks by UVSSA.

Rowyn Church LiebauCrystal WatersArooba AhmedRajesh K SoniJean Gautier

Published in: bioRxiv : the preprint server for biology (2023)

UVSSA facilitates transcription-coupled DNA interstrand crosslink repair by recruiting TFIIH to transcription machinery stalled at the lesion. Transcription-coupled ICL repair is required for survival following crosslink inducing drug exposure.

Keyphrases

transcription factor
circulating tumor
cell free
emergency department
adverse drug
electronic health record
circulating tumor cells