Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis.
Shmulik AvlasGuy ShaniNatalie RhoneMichal ItanAvishay DolitzkyInbal HazutSharon Grisaru-TalYaara GordonTetsuo ShodaAdina BallabanNetali Morgenstern Ben-BaruchMark RochmanYael DiesendruckLimor NaharyAlmog BittonZamir HalpernItai BenharChen VarolMarc E RothenbergAriel MunitzPublished in: Allergy (2022)
We demonstrate a definitive role for IL-13 signaling via IL-13Rα1 in EoE. These data provide mechanistic insights into the mode of action of current therapies in EoE and highlight the type II IL-4R as a future therapeutic target.
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