Site-specific 68 Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models.
Jonatan DewulfTal FlieswasserTim DelahayeChristel VangestelAlan MirandaHans de HaardJulie JacobsEvelien SmitsTim Van den WyngaertFilipe ElvasPublished in: EJNMMI radiopharmacy and chemistry (2023)
Ga]Ga-NOTA-anti-CD70 VHH showed excellent in vivo targeting of CD70 in human cancer xenografts. PET imaging using this radioimmunoconjugate holds promise as a non-invasive method to identify and longitudinally follow-up patients who will benefit most from anti-CD70 therapies.