Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance.

Alex PearsonPaula ProszekJavier PascualCharlotte FribbensMonee K ShamsherBelinda KingstonBen O'LearyMaria T Herrera-AbreuRosalind J CuttsIsaac Garcia-MurillasHannah ByeBrian A WalkerDavid Gonzalez De CastroLina YuanSabri Jamal Michael HubankElena Lopez-KnowlesEugene F SchusterMitch DowsettPeter OsinAshutosh NerurkarMarina PartonAlicia F C OkinesStephen R D JohnstonAlistair RingNicholas C Turner

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our research identifies multiple therapeutic opportunities for advanced breast cancer and identifies the previously underappreciated acquisition of NF1 mutations.

Keyphrases

signaling pathway
lps induced
genome wide
pi k akt
oxidative stress
nuclear factor
gene expression
bone marrow
breast cancer risk