Evaluating group-sequential non-inferiority clinical trials following interim stopping: The HIV Prevention Trials Network 083 trial.

Brett S Hanscom Deborah J DonnellThomas R FlemingJames P HughesMarybeth McCauleyBeatriz GrinsztejnRaphael J LandovitzScott S Emerson

Published in: Clinical trials (London, England) (2022)

For the HIV Prevention Trials Network 083 trial, the difference between corrected inferential statistics and naive results was quite small-as will often be the case-nevertheless, it is appropriate to report and publish the most accurate and unbiased statistical results.

Keyphrases

clinical trial
phase iii
phase ii
study protocol
open label
hiv infected
double blind
network analysis