Comparison between Local Excision and Radical Resection for the Treatment of Rectal Cancer in ypT0-1 Patients: An Analysis of the Clinicopathological Factors and Survival Rates.
Soo Young OhIn-Ja ParkYoung Il KimJong-Lyul LeeChan Wook KimYong Sik YoonSeok-Byung LimChang-Sik YuJin Cheon KimPublished in: Cancers (2021)
Tumors with good response to preoperative chemoradiotherapy have a favorable prognosis, and these findings raise interest in rectum-sparing strategies. This study aimed to compare the oncologic outcome between local excision and radical resection in ypT0-1 patients and to analyze prognostic factors. Patients with primary rectal cancer diagnosed with ypT0-1 after PCRT followed by either radical resection (RR) or local excision (LE) between 2005 and 2014 were included in this study (LE = 78, RR = 442). Clinicopathologic features, recurrence-free survival (RFS), and OS were analyzed. There was no statistically significant difference in the RFS and OS between the LE and RR groups. Clinical T stage (cT3-4) before PCRT was related to RFS and in the LE group (p = 0.022). Lymph node metastasis (HR: 4.884, 95% confidence interval: 2.451-9.732, p < 0.001) in the final pathology was the only factor associated with RFS, showing a statistically significant difference in the RR group. Lymph node metastasis and age were associated with OS in the RR group. This study confirms the oncologic feasibility of LE in ypT0-1 rectal cancer after PCRT. Additionally, careful patient selection with higher accuracy modalities should be updated to improve treatment outcomes of LE.
Keyphrases
- rectal cancer
- lymph node metastasis
- prognostic factors
- locally advanced
- free survival
- end stage renal disease
- squamous cell carcinoma
- chronic kidney disease
- ejection fraction
- computed tomography
- magnetic resonance imaging
- patients undergoing
- magnetic resonance
- robot assisted
- dual energy
- drug induced
- replacement therapy