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Sex Differences in Characteristics, Outcomes and Treatment Response with Dapagliflozin across the Range of Ejection Fraction in Patients with Heart Failure: Insights from DAPA-HF and DELIVER.

Xiaowen WangMuthiah VaduganathanBrian Lee ClaggettSheila M HegdeMaria PabonIan J KulacOrly VardenyEileen O'MearaShelley ZierothTzvetana KatovaMartina M McGrathAnne-Catherine PouleurPardeep S JhundAkshay S DesaiCatherine M ViscoliMikhail Naum KosiborodRudolf A de BoerLars Valeur KøberMarc S SabatineFelipe A MartinezPiotr PonikowskiSanjiv J ShahAdrian F HernandezAnna Maria LangkildeJohn Joseph Valentine McMurrayScott D SolomonCarolyn Su Ping Lam
Published in: Circulation (2022)
In DAPA-HF and DELIVER, the response to dapagliflozin was similar between men and women. Sex did not modify the treatment effect of dapagliflozin across the range of ejection fraction.
Keyphrases
  • ejection fraction
  • aortic stenosis
  • acute heart failure
  • heart failure
  • type diabetes
  • skeletal muscle
  • left ventricular
  • transcatheter aortic valve replacement
  • insulin resistance