Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe.

Meng-Meng ZhangYin-Hua MaPeng LiYan JiaKe-Li Han

Published in: Chemical communications (Cambridge, England) (2020)

We have synthesized a turn-on fluorescent probe, termed NB4OH, to detect cellular hypochlorite. NB4OH is mainly localized in the endoplasmic reticulum and detects ClO- in foam cells. The fluorescence change of the probe was explained by theoretical calculation as a PET process. The probe holds great promise for application in biomedical research, including atherosclerosis research.

Keyphrases

living cells
fluorescent probe
endoplasmic reticulum
induced apoptosis
single molecule
cell cycle arrest
cardiovascular disease
quantum dots
pet ct
signaling pathway
cell death
cell proliferation
big data
label free
loop mediated isothermal amplification